Rhophylac 300 Anti-D is used to prevent the formation of antibodies against the Rh factor in the blood of women, for prophylaxis during pregnancy or after delivery in cases of Rh-incompatible pregnancies.

Indications for Use of Rhophylac 300

Rhophylac anti d injection is used to prevent the formation of antibodies against the Rh factor in the blood in cases of:

• Pregnancy and obstetric conditions in non-sensitized Rh-negative women with an Rh-incompatible pregnancy (Rh-positive fetus). This includes routine antepartum Rh prophylaxis, as well as prophylaxis after delivery, in case of obstetric complications, or when invasive procedures are required.

• Incompatible blood transfusions in Rh-negative individuals who receive blood components containing Rh-positive red blood cells.

Immune Thrombocytopenic Purpura (ITP): Rhophylac injections are also used to raise platelet counts in Rh-positive, non-splenectomized adults with chronic ITP.

Dosage and Administration

Anti d injection dose during pregnancy and obstetric

• Route: Intravenous (IV) or intramuscular (IM).

• Routine antepartum prophylaxis: A single dose of 300 mcg at 28–30 weeks of pregnancy.

• Postpartum prophylaxis: A single dose of 300 mcg within 72 hours after delivery.

• Obstetric complications or invasive procedures: 300 mcg within 72 hours of the complication or intervention.

Dosage for Incompatible Blood Transfusions

• 20 mcg per 2 mL of Rh-positive whole blood transfused, or per 1 mL of Rh-positive red blood cells.

Dosage for Immune Thrombocytopenic Purpura (ITP)

• 50 mcg per kg of body weight, administered intravenously at a rate of 2 mL every 15–60 seconds.

Side Effects of Rhophylac Anti-D Injection

Rhophylac 300 may cause some side effects, such as:

• Nausea

• Dizziness

• Headache

• Pain at the injection site

• Fever

• Chills

• Hemolysis

Contraindications

Rhophylac injection should not be used in cases of:

• Hypersensitivity to its components.

• Anemia in patients with Immune Thrombocytopenic Purpura (ITP).

Storage and Handling

• Keep out of reach of children.

• Store at a temperature between 2–8 °C.

• Do not freeze.

• Keep in the original package, protected from light.

• Do not store at room temperature, as the product contains no preservatives.