What Desvenlafaxine  is used for :

Desvenlafaxine  is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), indicated for the treatment of major depressive disorder.

 

Do not use Desvenlafaxine :

Hypersensitivity to Desvenlafaxine  succinate, venlafaxine hydrochloride or any excipients

Do not use with an MAOI or within 14 days of stopping an MAOI.

Allow 7 days after stopping Desvenlafaxine  before starting an MAOI

 

Warnings and precautions :

Clinical Worsening/Suicide Risk: Monitor for clinical worsening and suicide risk 

Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions: Serotonin syndrome or NMS-like reactions have been reported with SSRIs and SNRIs.

Discontinue Desvenlafaxine  and initiate supportive treatment

Elevated Blood Pressure: Has occurred with Desvenlafaxine .

Hypertension should be controlled before initiating treatment.

Monitor blood pressure regularly during treatment

Abnormal Bleeding: Desvenlafaxine  may increase the risk of bleeding events.

Patients should be cautioned about the risk of bleeding associated with the concomitant use of Desvenlafaxine  and NSAIDs, aspirin, or other drugs that affect coagulation 

Narrow-angle Glaucoma: Mydriasis has occurred with Desvenlafaxine .

Patients with raised intraocular pressure or those at risk of angle-closure glaucoma should be monitored 

Activation of Mania/Hypomania: Has occurred.

Use cautiously in patients with Bipolar Disorder.

Caution patients about the risk of activation of mania/hypomania 

Cardiovascular/Cerebrovascular Disease:

Use cautiously in patients with cardiovascular or cerebrovascular disease Cholesterol and Triglyceride Elevation:

Use cautiously in patients with lipid metabolism disorders. Consider monitoring serum cholesterol and triglyceride 

Discontinuation Symptoms: Have occurred.

Taper the dose when possible and monitor for discontinuation symptoms 

Renal Impairment: Reduces the clearance of Desvenlafaxine . Dosage adjustment is necessary in severe and ESRD. In moderate renal impairment, the dose should not exceed 50 mg/day 

Seizure: Can occur. Use cautiously in patients with seizure disorder 

Hyponatremia: Can occur in association with SIADH 

Drugs Containing Desvenlafaxine  or Venlafaxine: Should not be used concomitantly with it

Interstitial Lung Disease and Eosinophilic Pneumonia: Can occur

 

Possible Side Effects :

Stop using the product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing.

Stop using the product if you develop hives or itching of the face or body. 

 

Other Medicines and Desvenlafaxine  :

Especially tell your healthcare provider if you take:

other MAOIs

medicines to treat migraine headaches known as triptans

tricyclic antidepressants

fentanyl

lithium

tramadol

tryptophan

buspirone

amphetamines

St. John's Wort

other medicines containing Desvenlafaxine  or venlafaxine

medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin

medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)

 

How to Use Desvenlafaxine  :

Recommended dose: 50 mg once daily with or without food.

 

How to Store Desvenlafaxine  :

Store at 20° to 25°C.Do not use after the expiration date (EXP), which is on the container. 

The expiration date refers to the last day of that month.

Keep and all medicines out of the reach of children.