Glucovance ingredients
Glucovance contains:
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5 mg glibenclamide: from the second generation of sulfonylurea, helps reduce blood sugar levels by stimulating insulin release from the pancreas.
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500 mg Metformin: Biguanide, helps reduce blood sugar levels by reducing the liver's glucose production, delaying intestinal glucose absorption, and improving cell glucose utilization, increases insulin sensitivity but does not increase insulin secretion.
What is Glucovance 500- 5 used for?
Glucovance is used to control blood sugar levels in people with type 2 diabetes, especially with diet and exercise not succeeding in controlling blood sugar.
Glucovance 500/5 dosage
The appropriate dose is determined depending on the patient's condition and response.
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The dose usually starts with a daily glucovance tablet.
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The dose should be adjusted every two weeks or more by increasing 1 tablet, depending on the results of blood sugar levels.
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The maximum daily allowable dose is 3 glucovance 500/5 tablets, but in exceptional cases estimated by the doctor it may be 4 glucovance 500/5 tablets.
When is glucovance taken?
Glucovance tablets should be taken in the beginning of meals, and the time of taking them during the day depends on the number of doses:
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Once a day, tablet with breakfast.
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twice daily, or 2 - 4 tablets per day, morning and evening.
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3 times per day, or 3 tablets per day, in the morning, in the afternoon and in the evening.
The meal the patient takes after taking the drug should be rich enough with carbohydrates to prevent hypoglycemia.
Glucovance 500/5 side effects
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Vomiting.
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Diarrhea.
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Abdominal pain.
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anorexia.
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Taste disturbance.
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High levels of liver enzymes.
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Temporary vision disturbances at the beginning of treatment.
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Leukopenia.
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Thrombocytopenia.
Glucovance contraindications
Glucovance is not used in case of:
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Hypersensitivity to the ingredients of the drug.
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Metabolic acidosis.
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Kidney failure.
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Severe disorders that may impair kidney function, such as dehydration or severe infection.
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Heart or respiratory failure.
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Recent myocardial infarction.
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Porphyria.
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liver failure.
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Alcohol poisoning.
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breastfeeding.
Glucovance for Pregnant
There is insufficient data on the effect of taking glucovance during pregnancy, but the active substance glibenclamide may reach the fetus and cause its blood sugar levels to fall, so glucovance should not be taken during pregnancy and insulin may be used instead.
Glucovance and lactation
The drug may be transmitted through breast milk to the infant, so glucovance is not used during breastfeeding.
Drug interactions
The doctor should be consulted before taking glucovance along with any other medication, especially:
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Anticoagulants.
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Rifampicin.
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Verapamil.
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NSAIDs.
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Blood pressure drugs.
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Antifungal.
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Diuretics.
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corticosteroids.
