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Janumet 50/1000 ingredients
Janumet drug contains:
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50 mg sitagliptin: Dipeptidyl peptidase 4 "DPP-4" inhibitor, the enzyme that breaks down incretins, hormones released by the body after meal and stimulates pancreas to release insulin. By increasing their blood levels through the drug, the pancreas is furtherly stimulated to secrete more insulin.
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1000 mg of metformin: reduces blood sugar levels by reducing the production of glucose by the liver, increasing muscle sensitivity to insulin, and delaying intestinal glucose absorption.
What is Janumet 50mg used for?
Janumet is prescribed along with exercise and diet to improve blood sugar levels in people with type 2 diabetes if the drug is suitable for them.
Janumet 50/1000 dose
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Dosage is preferred based on the patient's needs.
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Usual dosage: 2 tablets per day, one in the morning, one in the evening.
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Janumet is preferred after meals.
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It is not recommended to take more than 2 tablets of Sinemet per day.
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The dose may vary if the drug is used with other diabetes medications, depending on the type of drug used, in order to avoid a drop in blood sugar levels.
Janumet 50/1000 side effects
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Upper respiratory tract infection.
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Nasopharyngitis.
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dizziness.
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headache.
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tremors.
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Blurred vision.
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Constipation.
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Nausea.
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gastroesophageal reflux.
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Diarrhea.
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Abdominal pain.
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Vomiting.
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excessive sweating.
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Skin rash.
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Itch.
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Joint pain.
Janumet contraindications
Janumet is not used in the case of:
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Allergy to drug ingredients.
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Acute metabolic acidosis.
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Severe kidney failure.
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Severe conditions that may impair kidney function, such as dehydration, severe infection or trauma.
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Heart or respiratory failure.
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Recent acute myocardial infarction.
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liver failure.
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Acute alcohol toxicity.
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breastfeeding.
Precautions
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Janumet is not a substitute for insulin, especially in patients whose diabetes treatment is based on insulin.
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Janumet is not used for type 1 diabetes or for the treatment of diabetic ketoacidosis.
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The drug is used with caution in case of kidney failure, and should be discontinued in case of severe kidney failure
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Janumet is not used in case of liver failure, and liver enzymes must be tested before and during the use of the drug.
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The drug may increase the risk of acute pancreatitis, and care should be taken before using it for those who have previously developed pancreatitis.
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You should stop taking Janumet prior to surgery requiring anesthesia, and resume taking it at least 48 hours after the operation or with the resumption of oral nutrition.
Janumet and pregnancy
There is insufficient data on the effect of the active substance during pregnancy, so it is not recommended to take Janumet during pregnancy.
Janumet and lactation
Janumet is not taken during breastfeeding, especially since the active substance metformin may be transmitted through breast milk and lead to lower blood sugar levels in the infant.
Drug interactions
The doctor should be consulted before taking Janumet along with any other medication, especially:
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Digoxin.
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Warfarin.
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Blood pressure drugs.
FAQs
Is Janumet safe for the kidneys?
Janumet is used with caution in case of renal insufficiency, and should be discontinued if the glomerular filtration rate decreases to 30 ml/min. The drug should not be taken if it suffers from disorders that may harm the kidneys, such as dehydration.
