Zympass – Dual Lipid Control Therapy, 30 Tablets

Zembas 20/10 mg is a medication combining Rosuvastatin 20 mg and Ezetimibe 10 mg. Used alongside an appropriate diet, it helps lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides in adults with primary hypercholesterolemia or familial hypercholesterolemia. It is also indicated when statin monotherapy is insufficient to achieve targeted cholesterol control, or as a substitution therapy for patients already taking Rosuvastatin and Ezetimibe concurrently at the same dosages.

Benefits and Uses of Zembas 20/10 mg

• Helps lower bad cholesterol (LDL-C) levels.

• Contributes to reducing total cholesterol and triglycerides.

• Helps improve blood lipid profile control when combined with a healthy diet.

• Contributes to reducing the risk of cardiovascular complications in certain high-risk patients, based on physician evaluation.

• Provides a combination therapy in a single tablet for patients requiring both Rosuvastatin and Ezetimibe.

Directions for Use

• Take 1 tablet once daily, with or without food, as directed by your doctor.

• It is recommended to maintain a low-fat, low-cholesterol diet throughout the treatment period.

• This product should not be used for initial therapy; appropriate dosages of the active ingredients must be established first before switching to the fixed-dose combination.

• If taking bile acid sequestrants, take Zembas at least 2 hours before or at least 4 hours after administration of the sequestrant.

Side Effects

Zembas may cause side effects, the most common of which include:

• Headache.

• Muscle pain or joint pain.

• Constipation or nausea.

• Abdominal pain or discomfort.

• Elevated liver enzymes in some cases.

• In rare cases, severe muscle injury such as rhabdomyolysis may occur, particularly in patients with risk factors. Consult a doctor immediately if you experience severe muscle pain or unexplained weakness accompanied by fever or dark urine.

Precautions and Warnings

• Contraindicated during pregnancy and breastfeeding.

• Do not use in patients with active liver disease or unexplained, persistent elevations in liver enzymes.

• Inform your doctor if you have a medical history of muscle disorders, kidney disease, or hypothyroidism.

• Your doctor may order periodic liver function and lipid profile tests during treatment.

• Do not discontinue or adjust the dosage without consulting your doctor.

Drug Interactions

Zembas may interact with certain medications, most notably:

• Cyclosporine.

• Warfarin and other anticoagulants.

• Gemfibrozil and other fibrates.

• Certain antiretrovirals used for HIV or viral hepatitis.

• Antacids containing aluminum or magnesium, as they may decrease the absorption of Rosuvastatin if taken simultaneously; doses should be separated.

• Bile acid sequestrants, which may reduce the absorption of Ezetimibe if taken at the same time.

Storage Conditions

• Store at a temperature not exceeding 30°C.

• Store in the original packaging to protect from moisture.

• Keep out of reach of children.

Ingredients

Active Ingredients:

• Rosuvastatin (as Rosuvastatin Calcium) 20 mg.

• Ezetimibe 10 mg.

Other Ingredients:

• Contains lactose monohydrate, along with other excipients used in the manufacture of the film-coated tablets.