Trivastal Retard 50 mg is a medication containing piribedil, a dopamine receptor agonist. Formulated as sustained-release tablets, it is used to treat Parkinson's disease—either as monotherapy in the early stages or in combination with levodopa to help improve the control of motor symptoms such as tremors, bradykinesia (slowness of movement), and muscle rigidity.
What is Trivastal retard 50 mg used for?
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Treatment of Parkinson's disease in adults.
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Helps improve motor symptoms, including:
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Tremors
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Bradykinesia (slowed movement)
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Muscle stiffness (rigidity)
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Used alone (monotherapy) in certain early-stage cases of the disease.
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Used in combination with levodopa to enhance therapeutic efficacy and help reduce motor fluctuations in some patients.
Trivastal 50 mg dose
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Take tablets orally after meals with a sufficient amount of water.
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Swallow the tablet whole; do not crush, chew, or divide it to preserve its sustained-release properties.
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The dosage is determined by a physician based on the patient's condition and individual response to treatment.
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Do not stop taking the medication abruptly without consulting your doctor, as sudden discontinuation may worsen symptoms.
Trivastal 50 mg side effects
Trivastal Retard may cause side effects, the most common of which include:
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Nausea or vomiting
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Gastrointestinal disturbances, such as indigestion
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Dizziness or drowsiness
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Headache
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Orthostatic hypotension (drop in blood pressure upon standing), which may lead to lightheadedness or fainting
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Hallucinations or confusion, particularly in elderly patients
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Sudden sleep onset episodes in some cases
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Impulse control disorders, such as compulsive gambling, increased shopping, hyperphagia (binge eating), or hypersexuality
What are the warnings for Trivastal?
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Contraindicated in individuals with a known hypersensitivity to piribedil or any of the inactive ingredients.
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Use with caution in patients with cardiovascular disease or hypotension.
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May cause drowsiness or sudden sleep attacks; refrain from driving or operating machinery until your response to the medication is established.
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Monitor for behavioral changes or impulse control disorders during treatment.
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Use during pregnancy or breastfeeding only if determined by a doctor that the potential benefits outweigh the possible risks.
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Safety and efficacy have not been established in children and adolescents under 18 years of age.
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Use with caution in patients with hepatic or renal impairment.
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Contains sucrose; therefore, it is not recommended for individuals with fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency.
Drug Interactions
Trivastal Retard may interact with certain medications, including:
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Antipsychotics that block dopamine receptors (e.g., haloperidol), as they may diminish the efficacy of piribedil.
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Sedatives, hypnotics, and alcohol, which may intensify drowsiness and dizziness.
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Antihypertensive drugs, as they may increase the risk of orthostatic hypotension.
Always inform your doctor or pharmacist of all medications, supplements, and herbal products you are taking before starting therapy.
Storage
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Store at a temperature below 25°C.
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Keep in the original packaging, away from moisture and direct heat.
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Keep out of reach of children.
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Do not use after the expiration date printed on the package.
Ingredients
Trivastal active ingredients:
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Piribedil: 50 mg per sustained-release tablet.
Inactive Ingredients:
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Povidone
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Magnesium stearate
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Talc
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Sodium hydrogen carbonate
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Sodium carboxymethylcellulose (Carmellose sodium)
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White beeswax
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Titanium dioxide (E171)
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Cochineal Red A / Ponceau 4R (E124)
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Polysorbate 80
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Sucrose
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Colloidal anhydrous silica
