pyrazinamide 500 mg is an anti-tuberculosis drug used to treat active tuberculosis (TB). It is typically administered alongside other anti-TB medications and is particularly effective against TB bacilli. It should only be used under strict medical supervision.

pyrazinamide uses

Pyrazinamide is an antibiotic used in combination with other drugs to treat TB in the following cases:

• Newly diagnosed pulmonary tuberculosis: During the first two months of treatment, it is used along with drugs like rifampicin, isoniazid, and ethambutol.

• Drug-resistant tuberculosis: Used when resistance to isoniazid and/or rifampicin is present, in combination with other suitable antibiotics.

How to Use

• Take the medication exactly as prescribed by your doctor.

• pyrazinamide dose:

• Adults: 3 to 4 tablets (500 mg each) once daily.

• Children: 20 mg per kilogram of body weight once daily, only if no suitable alternatives are available.

pyrazinamide side effects

Possible side effects include:

• Liver problems: Liver dysfunction, loss of appetite, nausea, vomiting, abdominal pain, fatigue, fever, jaundice.

• Blood and lymphatic issues: Rare cases of anemia, low platelet count, or porphyria.

• Nervous system: Occasionally headache, dizziness, insomnia, irritability.

• High uric acid: Common joint pain, gout attacks, and muscle pain.

• Kidneys and urinary tract: Changes in urine color, difficulty urinating, nephritis.

Other effects:

• Diabetic patients may face difficulty controlling blood sugar levels.

• Allergic reactions such as skin rash or photosensitivity.

Warnings and Precautions

• Do not use Pyrazinamide if you are allergic to it or any of its components.

• Inform your doctor about all other medications you're taking, including over-the-counter drugs and herbal supplements, as drug interactions may occur.

• Pyrazinamide is a potent medication and should be used only under medical supervision.

Drug Interactions

Possible interactions may occur with:

• Abacavir.

• Aceclofenac.

• Acemetacin.

• Acenocoumarol.

• Acetaminophen.

Note: Pyrazinamide may interact with other medications, so always consult your doctor before combining it with any other drugs.

pyrazinamide contraindications

Do not take this medication in the following cases:

• Known allergy to pyrazinamide or any of its ingredients.

• Liver failure.

• Confirmed high uric acid levels in the blood.

• Kidney failure (unless deemed absolutely necessary by the doctor).

• Porphyria.

• During pregnancy.

Storage and Handling

• Do not use the medication after the expiration date listed on the packaging.

• Store at a temperature not exceeding 25°C.

• Keep out of reach of children.

pyrazinamide tablet Ingredients

• Active Ingredient:

• 500 mg of pyrazinamide per tablet.

• Other Ingredients:

• Microcrystalline cellulose.

• Corn starch.

• Colloidal anhydrous silica.

• Magnesium stearate.