Metoject 10Mg / 0.2Ml Methotrexat 1 Prefilled Syring

What is a Metoject injection?

Metoject 10 mg/0.2 mL is a solution for subcutaneous injection containing methotrexate at a concentration of 10 mg in a pre-filled syringe. It is administered strictly once weekly to treat certain autoimmune diseases and chronic inflammatory conditions. It works by suppressing immune system activity and reducing inflammation, which helps relieve symptoms and slow disease progression.

Uses and Benefits of Metoject

• Treatment of active rheumatoid arthritis in adult patients.

• Treatment of polyarticular juvenile idiopathic arthritis in children and adolescents, as evaluated by a physician.

• Treatment of severe psoriasis and psoriatic arthritis when other therapies are inappropriate or ineffective.

• May be used for mild to moderate Crohn's disease in adult patients in selected cases, according to medical recommendations.

• Comes in a ready-to-use pre-filled syringe, ensuring precise dosing.

• Administered once weekly, which supports patient adherence to the treatment plan.

How to Use Metoject

• Use strictly according to your physician's prescription.

• Inject subcutaneously ONCE WEEKLY only; do not use daily.

• The injection may be administered into the abdomen or thigh, alternating the injection site each time.

• Your doctor may recommend taking folic acid to help reduce certain side effects.

• Adhere strictly to follow-up appointments and routine laboratory testing throughout treatment.

• If a dose is missed, contact your physician immediately to determine the correct protocol; do not double the dose.

Side Effects

Metoject may cause side effects, the most common of which include:

• Nausea or vomiting

• Loss of appetite

• Stomatitis or mouth ulcers

• Fatigue and exhaustion

• Elevated liver enzymes

• Decreased blood cell counts, which may increase the risk of infection or bleeding

Rare but serious complications may occur, such as:

• Pulmonary inflammation or fibrosis

• Liver damage (hepatotoxicity)

• Renal impairment

• Severe bone marrow suppression

Seek immediate medical attention if you experience symptoms such as fever, persistent cough, shortness of breath, unusual bleeding, or yellowing of the skin and eyes (jaundice).

Precautions and Warnings

• CONTRAINDICATED IN PREGNANCY: Methotrexate can cause fetal death or severe congenital malformations.

• Effective contraception must be used during treatment and for a duration determined by the physician after discontinuation, for both male and female patients as applicable.

• Do not use while breastfeeding.

• Inform your doctor if you have liver or kidney disease, blood disorders, or active infections.

• Avoid alcohol consumption, as it significantly increases the risk of liver damage.

• Regular monitoring of liver function, renal function, and complete blood counts (CBC) is required during therapy.

• The medication increases susceptibility to infections; notify your doctor at the first sign of an infection.

• May cause photosensitivity; avoid excessive exposure to sunlight and use proper sun protection.

Drug Interactions

Methotrexate may interact with numerous medications, including:

• Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

• Certain antibiotics, such as co-trimoxazole and penicillins

• Leflunomide

• Proton Pump Inhibitors (PPIs)

• Live vaccines

• Medications that affect liver or kidney function

Always inform your physician or pharmacist of all medications, supplements, and herbal products you are taking before starting treatment.

Storage

• Store at a temperature not exceeding 25°C.

• Keep in the original package to protect from light.

• Do not freeze.

• Keep out of reach of children.

• Do not use after the expiration date printed on the package.

Ingredients

Active Ingredient:

• Methotrexate: 10 mg/0.2 ml

Inactive Ingredients:

• May include:

• Sodium chloride

• Sodium hydroxide (for pH adjustment)

• Water for injection

IMPORTANT WARNING: Metoject is administered ONCE WEEKLY ONLY and must NEVER BE USED DAILY. It must be used strictly under the supervision of a specialized physician, as incorrect dosing can lead to severe and potentially fatal complications, including severe bone marrow suppression, liver, kidney, and lung toxicity. It is STRICTLY CONTRAINDICATED during pregnancy due to the risk of fetal death and severe birth defects.