Aprolin Amarox Ingredients
Aprolin Amarox contains the active substance "hydralazine", the hydralazine mechanism of action is not yet fully understood, but it lowers blood pressure by dilating blood vessels, and may also prevent the movement of calcium within smooth muscles in blood vessels (Calcium leads to the contraction of those muscles, and hence the narrowing of blood vessels and high blood pressure, inhibition of its movement prevents this, contributing to the relaxation of those muscles and lowering blood pressure).
Aprolin Amarox Uses
Hydralazine 25 mg or Aprolin uses include:
-
Essential hypertension.
-
Lowering blood pressure along with other pressure drugs, such as beta blockers and diuretics.
Aprolin Amarox Dose
-
The doctor determines the appropriate dose depending on the patient's condition and his blood pressure response.
-
Initial dosage: 10 mg 4 times per day for the first 2 - 4 days.
-
Rest of the first week: 25 mg 4 times per day.
-
Rest of treatment: 50 mg 4 times per day for the second week and the following weeks.
-
Maintenance dosage: The lowest possible dose achieves the required efficacy.
Aprolin Amarox Side Effects
Aprolin may cause some side effects, such as:
-
Increased heart rate.
-
Palpitations.
-
Anginal symptoms, such as chest pain.
-
headache.
-
digestive disorders.
These side effects are more frequent at the beginning of the treatment, especially as the dose increases rapidly, but these symptoms do not persist during the duration of the treatment or after the dose reduction.
Aprolin Contraindications
Aprolin is not used in the case of:
-
Hypersensitivity to the ingredients of the drug.
-
Idiopathic systemic lupus erythematosus and related diseases.
-
Severe tachycardia.
-
Heart failure with high cardiac output (as in the case of hyperthyroidism).
-
Myocardial insufficiency due to mechanical obstruction, such as in the case of aortic or mitral stenosis, or constrictive pericarditis.
-
Right ventricular failure as a result of pulmonary hypertension.
-
Acute dissecting aneurysm of aorta.
-
Coronary artery disease.
Precautions
The doctor should be consulted before taking Aprolin, especially in the case of:
-
Systemic lupus erythematosus.
-
Heart failure or coronary artery disease.
-
Pregnancy and lactation.
Aprolin and Pregnancy
Animal studies have shown that high doses of hydralazine (Aprolin), can lead to congenital abnormalities in mice, such as cleft palate and facial and skull bone abnormalities.
There are insufficient studies of its impact on the pregnant, but its clinical use has shown that there is no risk to the fetus, yet the drug is used during pregnancy only if its benefits are higher than its risks under the supervision of a doctor.
Aprolin and Lactation
The active substance hydralazine may be transmitted via breast milk to the infant, so the doctor should be consulted to seek a suitable alternative during the breastfeeding period.
Drug Interactions
The doctor should be consulted before taking Aprolin along with any other medication, especially:
-
Vasodilators.
-
Other blood pressure drugs.
-
Diuretics.
-
Tricyclic antidepressants.
-
Beta-blockers.
-
Monoamine oxidase inhibitors.
