What Desvenlafaxine is used for :
Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), indicated for the treatment of major depressive disorder.
Â
Do not use Desvenlafaxine :
Hypersensitivity to Desvenlafaxine succinate, venlafaxine hydrochloride or any excipients
Do not use with an MAOI or within 14 days of stopping an MAOI.
Allow 7 days after stopping Desvenlafaxine before starting an MAOI
Â
Warnings and precautions :
Clinical Worsening/Suicide Risk: Monitor for clinical worsening and suicide riskÂ
Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions: Serotonin syndrome or NMS-like reactions have been reported with SSRIs and SNRIs.
Discontinue Desvenlafaxine and initiate supportive treatment
Elevated Blood Pressure: Has occurred with Desvenlafaxine .
Hypertension should be controlled before initiating treatment.
Monitor blood pressure regularly during treatment
Abnormal Bleeding: Desvenlafaxine may increase the risk of bleeding events.
Patients should be cautioned about the risk of bleeding associated with the concomitant use of Desvenlafaxine and NSAIDs, aspirin, or other drugs that affect coagulationÂ
Narrow-angle Glaucoma: Mydriasis has occurred with Desvenlafaxine .
Patients with raised intraocular pressure or those at risk of angle-closure glaucoma should be monitoredÂ
Activation of Mania/Hypomania: Has occurred.
Use cautiously in patients with Bipolar Disorder.
Caution patients about the risk of activation of mania/hypomaniaÂ
Cardiovascular/Cerebrovascular Disease:
Use cautiously in patients with cardiovascular or cerebrovascular disease Cholesterol and Triglyceride Elevation:
Use cautiously in patients with lipid metabolism disorders. Consider monitoring serum cholesterol and triglycerideÂ
Discontinuation Symptoms: Have occurred.
Taper the dose when possible and monitor for discontinuation symptomsÂ
Renal Impairment: Reduces the clearance of Desvenlafaxine . Dosage adjustment is necessary in severe and ESRD. In moderate renal impairment, the dose should not exceed 50 mg/dayÂ
Seizure: Can occur. Use cautiously in patients with seizure disorderÂ
Hyponatremia: Can occur in association with SIADHÂ
Drugs Containing Desvenlafaxine or Venlafaxine: Should not be used concomitantly with it
Interstitial Lung Disease and Eosinophilic Pneumonia: Can occur
Â
Possible Side Effects :
Stop using the product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing.
Stop using the product if you develop hives or itching of the face or body.Â
Â
Other Medicines and Desvenlafaxine :
Especially tell your healthcare provider if you take:
other MAOIs
medicines to treat migraine headaches known as triptans
tricyclic antidepressants
fentanyl
lithium
tramadol
tryptophan
buspirone
amphetamines
St. John's Wort
other medicines containing Desvenlafaxine or venlafaxine
medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin
medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)
Â
How to Use Desvenlafaxine :
Recommended dose: 50 mg once daily with or without food.
Â
How to Store Desvenlafaxine :
Store at 20° to 25°C.Do not use after the expiration date (EXP), which is on the container.Â
The expiration date refers to the last day of that month.
Keep and all medicines out of the reach of children.
