Pk-Merz 100Mg - 100 Tablets is a medication presented as film-coated tablets containing the active ingredient Amantadine Sulfate, a compound that affects the central nervous system. It has dual properties: antiparkinsonian and antiviral. It is used to improve motor symptoms such as rigidity, tremor, and bradykinesia by inhibiting NMDA receptors in the brain.

Indications for Use

PK-Merz is used in the treatment of the following conditions:

• Parkinson’s disease and drug-induced extrapyramidal syndrome.

• Motor dysfunctions following stereotactic brain surgery.

• Post-herpetic neuralgia (PHN).

• As an adjunct therapy in Hepatitis C with interferon and ribavirin.

• As monotherapy for Hepatitis C in patients unable to use ribavirin or who did not respond to interferon therapy.

pk-merz tablet dose 

For Parkinson’s disease

• Start with 2 tablets daily, gradually increased to 1 tablet 2–3 times per day.

• In advanced cases, the dose may reach 5 tablets daily, divided throughout the day.

For drug-induced extrapyramidal symptoms

• 1 tablet twice daily.

For Hepatitis C treatment

• Adjunct therapy: 1 tablet twice daily for 6 months with interferon and ribavirin.

• Monotherapy: 1 tablet twice daily for 6 months.

Note: Tablets should be taken with a small amount of liquid, preferably in the morning and afternoon to avoid sleep disturbances.

pk-merz side effects

• Sleep disturbances, insomnia, agitation.

• Visual hallucinations, especially in elderly patients.

• Dry mouth, constipation, difficulty urinating.

• Neurological disturbances in patients with arteriosclerosis.

Warnings and Precautions

• Contraindications:

• Hypersensitivity to amantadine.

• Prostatic hypertrophy.

• Narrow-angle glaucoma.

• Epilepsy.

• Myasthenia gravis.

• Pregnancy and Breastfeeding:

• Amantadine is considered teratogenic and should only be used during pregnancy when absolutely necessary after evaluating risks and benefits.

• It passes into breast milk; breastfeeding should be discontinued or the infant monitored for side effects such as rash, vomiting, or urinary retention.

• Caution:

• Use with care in elderly patients or those with kidney disease; dose adjustment may be necessary.

Drug Interactions

• Anticholinergic drugs may enhance the effects of amantadine.

• Inform your doctor of all medications being taken to avoid potential interactions.

Storage

• Store at room temperature between 15–30°C.

• Keep away from moisture and light.

Ingredients of Pk-Merz 100Mg

• Contains the active ingredient: Amantadine Sulfate 100 mg.