Metoject 20 mg/0.4 ml is a pre-filled injection used to treat rheumatoid arthritis, psoriasis, and psoriatic arthritis, especially in cases where other treatments have failed to control psoriasis. It contains 20 mg of methotrexate in a ready-to-use injectable form.

Composition of Metoject

Each pre-filled Metoject syringe contains the active ingredient methotrexate, which inhibits several enzymes, helping to reduce inflammation and prevent cell division.

Metoject 20mg prefilled syringe uses

Metoject injections are used in the treatment of:

• Active rheumatoid arthritis in adults.

• Severe, treatment-resistant psoriasis that interferes with daily life and does not respond to other treatments such as phototherapy or retinoids.

• Severe psoriatic arthritis in adults.

How to use Metoject syringe?

• Methotrexate injections are administered subcutaneously once a week.

• The medication must be used under medical supervision.

• The doctor will determine the appropriate dose based on the patient’s condition.

• It typically takes 4 to 8 weeks for the therapeutic effect to appear.

• Overdosing can be fatal; the prescribed dosage must be strictly followed.

• Not suitable for children under 3 years of age.

Metoject pen side effects

Methotrexate may cause the following side effects:

• Mouth inflammation

• Indigestion

• Loss of appetite

• Abdominal pain

• Abnormal liver function test results

• Mouth ulcers

• Diarrhea

• Skin rash and itching

• Skin redness

• Headache

• Fatigue

• Dizziness

• Decreased blood cell count

Contraindications for Metoject Injection

Metoject should not be used in the following cases:

• Hypersensitivity to its components

• Severe kidney or liver disease

• Blood disorders

• Regular consumption of large amounts of alcohol

• Serious infections (e.g., tuberculosis, HIV, or any immune-compromising diseases)

• Mouth, stomach, or intestinal ulcers

• Pregnancy and breastfeeding

• Receiving live vaccines concurrently with treatment

Warnings and Precautions

Consult your doctor before using methotrexate injections for rheumatoid arthritis, especially if you:

• Are elderly or feel weak and fatigued

• Have liver problems

• Are dehydrated

Avoid skin or mucous membrane contact with the medication; in case of accidental exposure, wash the affected area with water immediately.

Metoject and Pregnancy

Metoject is not recommended during pregnancy as it may cause miscarriage or severe fetal abnormalities. Pregnancy should be avoided during treatment and for up to six months after stopping the medication.

Metoject and Breastfeeding

Breastfeeding should be discontinued before and during treatment with Metoject.

Does Metoject affect fertility?

Metoject (methotrexate) may temporarily affect sperm production in men and egg production in women, but these effects are generally reversible.

Drug Interactions

Consult a doctor or pharmacist before using Metoject alongside other medications, including:

• Antibiotics

• Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen

• Probenecid

• Diuretics

• Other rheumatoid arthritis medications like sulfasalazine

• Mercaptopurine

• Retinoids (used for psoriasis and skin disorders)

• Diabetes medications

• Medications for stomach ulcers or acid reflux, such as omeprazole

Storage Instructions

• Keep out of reach of children

• Store below 25°C

• Do not use after the expiration date