ZESTRIL 20 MG TAB

What is lisinopril and what is it used for?

Lisinopril belongs to a group of medicines called ACE inhibitors.

It can be used for the following conditions:

• To treat high blood pressure (hypertension).

• To treat heart failure.

• If you have recently had a heart attack (myocardial infarction).

• To treat kidney problems caused by type 2 diabetes in people with high blood pressure.

It works by making blood vessels widen. This helps lower blood pressure. It also makes it easier for your heart to pump blood to all parts of your body.

Do not take lisinopril

• If you are allergic to lisinopril or any of the other ingredients of this medicine

• If you have ever had an allergic reaction to another ACE inhibitor. An allergic reaction may have caused swelling of the hands, feet, ankles, face, lips, tongue or throat. It may also have made it difficult to swallow or breathe (angioedema).

• If you have taken or are taking sacubitril/valsartan, a medicine used to treat a type of long-term (chronic) heart failure in adults, the risk of developing angioedema (rapid swelling under the skin in an area such as the throat) has increased.

• If someone in your family has had a severe allergic reaction (angioedema) to an ACE inhibitor or you have had a severe allergic reaction (angioedema) with no known cause.

• If you are more than 3 months pregnant.

• If you suffer from diabetes or impaired kidney function and are being treated with a medicine to lower blood pressure that contains aliskiren.

Warnings and precautions

Talk to your doctor or pharmacist before taking lisinopril if you:

• Narrowing (stenosis) in the aorta (an artery in your heart) or narrowing of the heart valves (mitral valves).

• You have a narrowing (narrowing) of a kidney artery.

• An increase in the thickness of the heart muscle (known as myocardial hypertrophy).

• You have problems with the blood vessels (collagen vascular disease).

• Reduction of Blood pressure. You may notice this as feeling dizzy or lightheaded, especially when standing up.

• You have kidney problems or have dialysis.

• Have liver problems.

• Diabetic.

• Take any of the following medicines used to treat high blood pressure: angiotensin II receptor blockers (ARBs), aliskiren

• You have recently had diarrhea or vomiting (illness).

• You have high cholesterol levels and are undergoing a treatment called “LDL apheresis”.

• Of black origin because lisinopril may be less effective. You may also more easily get the side effect ""angioedema"" (a severe allergic reaction).

Possible side effects of lisinopril

Common side effects

• Headache.

• Feeling dizzy or lightheaded, especially if you stand up quickly.

• Diarrhea.

• A dry cough that does not go away.

• Illness (vomiting).

• Kidney problems (shown in a blood test).

Other medicines and lisinopril

In particular, tell your doctor or pharmacist if you are taking any of the following medicines:

• Other medicines to help lower blood pressure.

• Angiotensin II receptor blockers (ARB) or aliskiren.

• Water tablets (diuretics).

• Beta-blocker drugs, such as atenolol and propranolol.

• Nitrates (for heart problems).

• Non-steroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and arthritis.

• Aspirin (acetylsalicylic acid) if you take more than 3 grams each day.

• Medicines for depression and mental problems, including lithium.

Potassium supplements (including salt substitutes), potassium-sparing diuretics, and other medicines that can increase the amount of potassium in the blood (eg, trimethoprim and co-trimoxazole for infections caused by bacteria; cyclosporine, an immunosuppressive medicine used to prevent rejection of transplanted organs; heparin A medicine used to thin the blood to prevent clots).

• Insulin or oral medications for diabetes.

• Medicines used in the treatment of asthma.

• Medicines for nasal or sinus congestion or other cold remedies (including medicines you can buy at a pharmacy).

• Medications to suppress the body's immune response (immunosuppressants).

• Allopurinol (for gout).

• Procainamide for heart rhythm problems.

• Medicines that contain gold, such as sodium aurothiomalate, which can be given to you as an injection.

How to take lisinopril

adults

Your dose is based on your medical condition and whether you are taking any other medications. Your doctor will tell you how many tablets to take each day. Consult your doctor or pharmacist if you are not sure.

• For high blood pressure: The recommended starting dose is 10 mg once a day. The usual long-term dose is 20 mg once a day.

• For heart failure: The recommended starting dose is 2.5 mg once a day. The long-term dose is 5 to 35 mg once a day.

• After a heart attack: The recommended starting dose is 5 mg within 24 hours of the attack and 5 mg one day after. The usual long-term dose is 10 mg once a day.

• For kidney problems caused by diabetes: The recommended dose is either 10 mg or 20 mg once a day. If you are elderly, have kidney problems, or take diuretic medications, your doctor may give you a lower than usual dose.

Use in children and adolescents (6-16 years of age) with high blood pressure

• This medicine is not recommended for children under 6 years of age or for children with severe kidney problems.

• Your doctor will determine the correct dose for your child. The dosage depends on the child's body weight.

• For children between 20 kg and 50 kg, the recommended starting dose is 2.5 mg once a day.

• For children weighing more than 50 kg, the recommended starting dose is 5 mg once a day.